Fully-coupled DEM-CFD simulation of low-density lipoprotein cholesterol particles behaviour in coronary arteries

Coronary artery plaque build-up which can lead to heart attack is mainly caused by low-density lipoprotein (LDL) cholesterol in blood stream.  In addition to the concentration of LDL cholesterol, hydrodynamics of blood as well as stiffness of coronary arteries wall can have significant influence on the deposition and build-up of plaques. In this project, a combined discrete-continuum approach based on fully coupled DEM-CFD simulation will be used to analyse the conditions which lead to deposition of LDL cholesterol within blood flow in coronary arteries.